College Football Week 3 Picks, Odds, and Predictions

Your ultimate guide to betting on Week 3 of the 2025 college football season, with expert analysis, key trends, and the latest odds from bet105.

Week 3 of the 2025 college football season is here, and it’s packed with thrilling matchups that could shake up the rankings. As conference play heats up and non-conference rivalries take center stage, there are plenty of opportunities for bettors to find value. This week features several high-stakes games, including a massive SEC showdown between Georgia and Tennessee, a pivotal non-conference clash with Texas A&M visiting Notre Dame, and a redemption-minded Alabama team hosting Wisconsin.

Before you lock in your bets, let’s dive into the key storylines, expert analysis, and betting trends that will shape this weekend’s action. We’ll break down the biggest games and provide insights to help you make informed wagers. All odds are courtesy of bet105.

Marquee Matchup: #6 Georgia at #15 Tennessee

Time: Saturday, 3:30 PM ET Odds: Georgia -3.5 (-109), Tennessee +3.5 (-105), O/U 49.5

One of the most anticipated games of the season takes place in Knoxville, where the #6 Georgia Bulldogs travel to face the #15 Tennessee Volunteers. This SEC rivalry has major implications for the conference championship and the College Football Playoff race. Georgia has dominated this series in recent years, winning the last seven meetings by an average of nearly 25 points. However, Tennessee is a much-improved team under coach Josh Heupel and will be looking to pull off a statement win at home.

Key Factors:

• Georgia’s Dominance: The Bulldogs have been a juggernaut in this series, and their defense is once again one of the best in the nation. They will look to shut down Tennessee’s high-powered offense and control the game on the ground.
• Tennessee’s Offense: The Volunteers have one of the most explosive offenses in the country, led by their star quarterback. They will need to find a way to score against Georgia’s stingy defense if they want to have a chance to win.
• Home Field Advantage: Neyland Stadium will be rocking for this game, and the home crowd could give Tennessee a significant boost.

Betting Trends:

• Georgia is 7-0 straight up in its last seven games against Tennessee.
• The total has gone UNDER in four of the last five meetings between these two teams.
• Tennessee is 5-1 against the spread in its last six games.

Prediction: This will be a close game, but Georgia’s defense will be the difference. The Bulldogs will do just enough to slow down Tennessee’s offense and come away with a hard-fought victory. Pick: Georgia -3.5

Non-Conference Showdown: #16 Texas A&M at #8 Notre Dame

Time: Saturday, 7:30 PM ET Odds: Texas A&M +7 (-114), Notre Dame -7 (+100), O/U 49.5

In a battle of top-20 teams, the #16 Texas A&M Aggies travel to South Bend to take on the #8 Notre Dame Fighting Irish. This is a massive non-conference game with significant implications for both teams’ playoff hopes. Notre Dame has been dominant at home, and they will be looking to make a statement against a talented Texas A&M team. The Aggies, on the other hand, are looking to prove that they are a legitimate national contender.

Key Factors:

• Notre Dame’s Home Field Advantage: Notre Dame Stadium is one of the toughest places to play in college football, and the Fighting Irish have been nearly unbeatable at home in recent years.
• Texas A&M’s Defense: The Aggies have one of the most talented defenses in the country, and they will need to be at their best to slow down Notre Dame’s offense.
• Quarterback Play: Both teams have talented quarterbacks, and the winner of this game could come down to which quarterback makes the most plays.

Betting Trends:

• Notre Dame is 10-0 straight up in its last 10 home games.
• Texas A&M is 4-1 against the spread in its last five games against non-conference opponents.
• The total has gone OVER in four of Notre Dame’s last five games.

Prediction: This will be a physical, hard-fought game. Texas A&M’s defense will keep them in the game, but Notre Dame’s home-field advantage will be too much to overcome. Pick: Notre Dame -7

Redemption Game: Alabama vs. Wisconsin

Time: Saturday, 12:00 PM ET Odds: Wisconsin +21 (-112), Alabama -21 (-102), O/U 46

After a stunning Week 1 loss to Florida State, Alabama bounced back with a dominant 73-0 victory over UL Monroe. Now, the Crimson Tide will look to continue their momentum as they host the Wisconsin Badgers. Alabama will be looking for a convincing win to prove that they are still a top contender, while Wisconsin will be looking to pull off a massive upset.

Key Factors:

• Alabama’s Motivation: The Crimson Tide will be highly motivated to put on a show after their early-season loss. They will be looking to make a statement and prove that they are still one of the best teams in the country.
• Wisconsin’s Rushing Attack: The Badgers have a powerful rushing attack that could give Alabama’s defense some problems. If Wisconsin can control the clock and keep Alabama’s offense off the field, they could have a chance to keep this game close.
• Alabama’s Run Defense: Alabama’s run defense has been surprisingly vulnerable this season, ranking 102nd in the nation. They will need to be much better against Wisconsin’s rushing attack if they want to win this game.

Betting Trends:

• Alabama is 10-0 straight up in its last 10 games against Big Ten opponents.
• Wisconsin is 2-6 against the spread in its last eight games as an underdog.
• The total has gone UNDER in five of Alabama’s last six games.

Prediction: Alabama is the more talented team, and they will be playing with a chip on their shoulder. The Crimson Tide will win this game, but Wisconsin’s rushing attack will do enough to keep it closer than the spread suggests. Pick: Wisconsin +21

Quick Picks for Other Notable Games

• LSU (-7.5) vs. Florida: LSU’s offense is firing on all cylinders, and they should be able to handle a Florida team that is still finding its identity. Pick: LSU -7.5
• Miami (-18.5) vs. USF: USF pulled off a huge upset last week, but they will have a much tougher time against a talented Miami team. Pick: Miami -18.5
• Oregon (-27.5) vs. Northwestern: Oregon is looking to make a statement in their first season in the Big Ten, and they should have no problem blowing out a struggling Northwestern team. Pick: Oregon -27.5

Disclaimer: Odds are subject to change. Please check bet105 for the latest odds.