Alabama vs. South Carolina: Betting Preview, Odds, and Prediction – Oct 25, 2025

A new era of Alabama football under head coach Kalen DeBoer faces a struggling South Carolina team in a Week 9 SEC showdown. We break down the matchup, analyze the latest bet105 odds, and provide a comprehensive betting prediction.

As Week 9 of the college football season approaches, all eyes are on the SEC matchup between the formidable Alabama Crimson Tide and the embattled South Carolina Gamecocks. The game, set to take place at Williams-Brice Stadium on Saturday, October 25, presents a classic David vs. Goliath scenario, with Alabama looking to continue its dominant run and South Carolina desperate to salvage a disappointing season.

The Resurgent Crimson Tide

Under the new leadership of Kalen DeBoer, the Crimson Tide have silenced any early-season doubts. After a narrow Week 1 loss to Florida State, Alabama has been on a tear, securing four consecutive victories against ranked opponents, including impressive wins over Georgia (24-21) and a 37-20 rout of Tennessee. Currently ranked #4 in the AP Poll, Alabama has demonstrated that the post-Nick Saban era is in capable hands.

Quarterback Ty Simpson has been a key factor in their success. In SEC road games, Simpson has been exceptional, averaging 238 passing yards with a 68.1% completion rate, 5 touchdowns, and zero interceptions. His poise and performance, particularly in high-pressure situations, have been instrumental in the team’s recent victories.

South Carolina’s Uphill Battle

The Gamecocks, on the other hand, are navigating a treacherous stretch of their schedule. With a 1-4 record in the SEC and 3-4 overall, the team has struggled to find its footing. Recent losses to LSU (20-10) and a crushing 26-7 defeat by Oklahoma, where the offense managed a meager 54 yards, have highlighted significant issues on the offensive side of the ball. The offensive line has been a particular point of weakness, allowing a high amount of pressure on the quarterback and stifling any attempts to build offensive momentum.

Head coach Shane Beamer faces an immense challenge in rallying his team against a powerhouse like Alabama, especially with a tough road ahead that includes matchups against Ole Miss and Texas A&M.

Betting Analysis

The betting markets reflect the stark contrast between these two teams. At bet105, the odds tell 

Alabama enters the game as a heavy favorite, and for good reason. Their potent offense, led by the efficient Ty Simpson, combined with a defense that makes crucial plays, presents a formidable challenge for any opponent, let alone a team with the offensive woes of South Carolina.

Expert predictions from across the sports world align with this sentiment. Multiple sources, including ESPN and Dimers.com, give Alabama an 80% or higher probability of winning. The consensus is that Alabama will not only win but also cover the spread.

Prediction

While a season-making upset is always a possibility in college football, the data and recent performances strongly suggest an Alabama victory. The Crimson Tide’s momentum, coupled with South Carolina’s offensive struggles, makes it difficult to envision a close contest.

The spread of -11.5 for Alabama seems more than achievable. Given their recent form and South Carolina’s inability to generate offense, a comfortable win for the Crimson Tide is the most likely outcome.

Final Score Prediction: Alabama 34, South Carolina 13

Read our predictions for other notable games in Week 9 of NCAA Football;

Oklahoma vs. Ole Miss – Saturday Oct. 25 at 12:00pm ET
Miami vs. Stanford – Saturday Oct. 25 at 7:00 pm ET

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