Kansas City Chiefs vs. Los Angeles Chargers: NFL Week 1 Betting Preview & Odds
Get ready for a thrilling AFC West showdown as the Kansas City Chiefs take on the Los Angeles Chargers

Get ready for a thrilling AFC West showdown as the Kansas City Chiefs take on the Los Angeles Chargers in a Week 1 NFL matchup in Sao Paulo, Brazil. This early-season divisional clash could have significant implications for the AFC playoff picture. At bet105, the Chiefs are favored by 3 points, but with both teams looking to start the season strong, this game is anything but predictable.
This comprehensive betting preview will break down the odds, analyze the key matchups, and provide expert predictions to help you make informed wagers. We’ll explore the strengths and weaknesses of both teams, the latest injury news, and how the unique setting in Brazil could impact the game’s outcome.
Chiefs vs. Chargers Odds: A Deep Dive into the Betting Lines
When analyzing the betting market for this AFC West clash, it’s crucial to understand the story the odds are telling. Here’s a detailed breakdown of the main betting lines available at bet105:
Point Spread: Chiefs -3 (-112)
The Kansas City Chiefs are currently favored by a field goal, with a -112 price on the -3 spread. This indicates that the market expects a close game, but gives a slight edge to the reigning AFC champions. A bet on the Chiefs at -3 would require them to win by more than three points to cash. Conversely, the Los Angeles Chargers are +3 underdogs at +102 odds, meaning a bet on them would win if they either win the game outright or lose by less than three points. The +102 price on the Chargers offers a slightly better payout than a standard -110 line, making it an attractive option for those who believe the Chargers can keep it close.
Total (Over/Under): 46.5
The game total is set at 46.5 points, with the over priced at -104 and the under at -108. This number suggests that the oddsmakers are anticipating a moderately high-scoring game, which is not surprising given the offensive firepower on both sides. However, it’s worth noting that the under is slightly more expensive at -108, which could indicate that there is some market sentiment leaning towards a lower-scoring affair. Early season games can sometimes be sloppy, and with both teams traveling to Brazil, a slower start is possible.
Moneyline: Chiefs -170, Chargers +152
The moneyline offers a straightforward way to bet on the winner of the game. The Chiefs are -170 favorites, meaning you would need to risk $170 to win $100. The Chargers are +152 underdogs, so a $100 bet on them would return a profit of $152 if they pull off the upset. The moneyline odds reflect the market’s confidence in the Chiefs, but the +152 price on the Chargers could be tempting for bettors who see value in the underdog.
Keys to the Game: Matchup Analysis and Betting Angles
To make an informed betting decision, it’s essential to look beyond the odds and analyze the key factors that will influence the outcome of this game. Here are some of the most important storylines to consider:
Can the Chargers Pressure Patrick Mahomes?
One of the biggest question marks heading into this game is whether the Chargers’ defense can generate enough pressure on Patrick Mahomes. Last season, the Chargers managed to sack Mahomes six times in two meetings, but their pass rush has lost some key pieces in the offseason. Without consistent pressure, Mahomes is a magician who can extend plays and find open receivers downfield. If the Chargers can’t get to him, it could be a long night for their secondary.
Will the Chiefs’ Offense Start Slow?
While the Chiefs have one of the most explosive offenses in the league, they could be facing some early-season headwinds. Star wide receiver Rashee Rice is suspended for this game, and rookie wideout Jalen Royals is also questionable. Additionally, veteran receiver Hollywood Brown is working his way back from an injury. These absences could limit the Chiefs’ big-play potential and force them to rely more on their running game and tight end Travis Kelce.
The Battle in the Trenches: Chargers’ Run Game vs. Chiefs’ Run Defense
The Chargers have made it clear that they want to establish a physical, run-heavy offense under new head coach Jim Harbaugh. They brought in running back Najee Harris to lead their ground attack, and he will be looking to make a statement in his first game with the team. The Chiefs’ run defense was a weakness at times last season, and if the Chargers can control the line of scrimmage and the clock with their running game, they will have a great chance to pull off the upset.
The Brazil Factor: How Will Travel and Field Conditions Impact the Game?
This game will be played in Sao Paulo, Brazil, which adds an extra layer of unpredictability. Both teams will have to deal with long travel and a new environment, which could lead to a sloppy, low-scoring game. The field conditions at Corinthians Arena were a major issue in last year’s game, and while the league has said that the turf has been improved, it’s still a factor to consider. A slow, low-scoring game would likely favor the underdog Chargers.
Predictions and Best Bets
After a thorough analysis of the odds, matchups, and key factors, here are our expert predictions for the Chiefs vs. Chargers game:
Best Bet: Los Angeles Chargers +3 (+102)
While the Chiefs are the rightful favorites, the +3 spread on the Chargers at +102 odds is too good to pass up. The Chargers have a new coach, a new offensive philosophy, and a talented roster that is capable of competing with the best teams in the league. With the Chiefs dealing with some key absences on offense and the game being played in a neutral location, the Chargers have a great chance to keep this game close and potentially win it outright. The +102 price provides excellent value for a team that has a legitimate path to victory.
Alternative Bet: Under 46.5 (-108)
If you’re not comfortable betting on the spread, the under 46.5 is another strong play. Early season games are often lower-scoring than expected, and with both teams traveling to Brazil, a slow start is a real possibility. The Chargers’ run-heavy offense will look to control the clock, and the Chiefs’ offense could be less explosive without some of their key weapons. The last three games between these two teams have all gone under the total, and we expect that trend to continue in this matchup.
Conclusion: A Must-Watch AFC West Showdown
This Week 1 matchup between the Chiefs and Chargers has all the makings of a classic. With two of the best quarterbacks in the league going head-to-head and a number of intriguing storylines to follow, this is a game that no football fan will want to miss. From a betting perspective, the value lies with the underdog Chargers, who have the talent and the game plan to keep this game close. Whether you’re betting on the spread, the total, or the moneyline, this is a game that is sure to provide plenty of excitement.