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Louisville vs. California: College Football Week 11 Betting Preview

A David vs. Goliath matchup is set for Week 11 of the college football season as the Louisville Cardinals

Louisville vs. California: College Football Week 11 Betting Preview

A David vs. Goliath matchup is set for Week 11 of the college football season as the Louisville Cardinals host the California Golden Bears. With Louisville firmly in the ACC championship hunt and California struggling to find its footing, this game presents a fascinating betting landscape. This comprehensive preview breaks down the odds, expert predictions, and key team insights to help you make informed wagers on bet105.

Betting Odds Overview

The betting markets paint a clear picture of a lopsided contest. Louisville is a heavy favorite across the board, but the specifics of the odds offer intriguing opportunities for bettors.

CategoryCaliforniaLouisville
Moneyline+744-1232
Spread+20.5 (-109)-20.5 (-105)
TotalOver 50.5 (-112)Under 50.5 (-104)

Odds courtesy of bet105.

Expert Predictions

While the experts unanimously predict a Louisville victory, their opinions on the margin of victory and the spread vary, offering valuable insights for bettors.

SourcePredictionKey Takeaway
Bookies.comBet Louisville to coverCalifornia’s recent struggles make them a risky bet against a strong Cardinals team.
Dimers.comLouisville 34, California 15A simulation model gives Louisville a 91% win probability.
ESPNLouisville 91.7% chance to winThe Worldwide Leader in Sports gives California a slim 8.3% chance of an upset.
Sporting NewsLouisville 38, California 20Louisville’s dominant running game will be too much for the Golden Bears to handle.
Sportsbook WireLouisville 37, Cal 15Louisville has struggled to cover large spreads this season (0-3 as 19.5-point favorites).

Team Analysis

Louisville Cardinals

The Cardinals are in the thick of the ACC championship race, and a win against California is crucial to their title hopes. Their offense is powered by a formidable rushing attack led by Isaac Brown, who has amassed 782 yards on an impressive 8.6 yards per carry. However, their performance against the spread has been less than stellar, particularly when heavily favored. They are 0-3 against the spread when favored by 19.5 points or more, a statistic that should give pause to those looking to bet on the Cardinals to cover.

California Golden Bears

California enters this game on a two-game losing streak and has struggled to cover the spread in their last four games. Despite their recent woes, the Golden Bears have shown flashes of competitiveness, particularly in close losses to Virginia Tech and Virginia. This will be their first time facing a double-digit spread this season, and it remains to be seen if they can keep the game closer than the experts predict.

Betting Angles and Conclusion

This game presents a classic “trap game” scenario for bettors. While Louisville is the clear favorite, their inability to cover large spreads makes the +20.5 for California an attractive option. The over/under of 50.5 is also a point of contention, with some experts predicting a high-scoring affair and others a more defensive battle.

For those looking for a safer bet, the moneyline on Louisville offers a high probability of a win, albeit with a small return. However, the real value in this game may lie in the spread. Given Louisville’s struggles to cover and California’s ability to keep games competitive, taking the Golden Bears and the points could be the most profitable play.

Ultimately, the decision is yours. Head over to bet105 to place your wagers and see how this ACC showdown unfolds.

Read our predictions for other notable games in Week 11 of NCAA Football;

Northwestern vs. USC – Friday, November 7, 2025 at 7:00pm ET
SMU vs. Boston College – Saturday, November 8, 2025 at 12:00pm ET
Oregon vs. Iowa – Saturday, November 8, 2025 at 3:30pm ET
Missouri vs. Texas A&M – Saturday, November 8, 2025 at 3:30pm ET
Florida State vs. Clemson – Saturday, November 8, 2025 at 7:00pm ET
Virginia vs. Wake Forest – Saturday, November 8, 2025 at 7:00pm ET
LSU vs. Alabama – Saturday, November 8, 2025 at 7:30pm ET