USC vs Notre Dame: Betting Preview, Odds, and Expert Picks for this Week 8 College Football Rivalry
A classic college football rivalry is renewed in Week 8 as the No. 20 USC Trojans travel to South

A classic college football rivalry is renewed in Week 8 as the No. 20 USC Trojans travel to South Bend to take on the No. 13 Notre Dame Fighting Irish. This marquee matchup promises high stakes and intense action, and for bettors, it presents a golden opportunity. At bet105, you can find a wide range of betting options for this game, from moneyline and spreads to totals and props. This article provides a comprehensive betting preview, expert analysis, and a breakdown of the odds to help you make informed wagers.
Team Analysis: USC Trojans
The USC Trojans bring one of the nation’s most explosive offenses to the table. Led by quarterback Jayden Maiava, who is averaging an impressive 10.8 yards per attempt, the Trojans rank second in the country in total offense with 552.3 yards per game and first in yards per play at 8.3. Wide receiver Makai Lemon, with 682 receiving yards and six touchdowns, is a game-changer, complemented by the reliable Ja’Kobi Lane. This offensive firepower makes USC a threat to score from anywhere on the field.
However, the Trojans are not without their concerns. The running game has been hit hard by injuries, with their top two running backs, Waymond Jordan and Eli Sanders, sidelined. While walk-on King Miller has filled in admirably, the drop-off in talent is a factor to consider. On the defensive side of the ball, USC has shown flashes of solid play, ranking 29th in success rate and holding five opponents under 380 total yards. However, they have also been susceptible to giving up big plays, as seen in their game against Illinois.
Team Analysis: Notre Dame Fighting Irish
Notre Dame enters this contest on a roll, having gone 3-0-1 against the spread in their last four games with an average margin of victory of 29.8 points. The Fighting Irish have been dominant on both sides of the ball. Their defense, after a slow start to the season, has been particularly impressive, allowing just 9.0 points per game over their last three contests. This unit will be a stiff test for the high-powered USC offense.
Offensively, Notre Dame is efficient, ranking 13th in EPA per play. However, they play at a slower pace, ranking 81st in plays per minute. The offense is led by redshirt freshman quarterback CJ Carr, who, despite his inexperience, has managed the game well. The key for Notre Dame will be to control the clock, limit USC’s possessions, and rely on their stout defense to win the game.
Betting Prediction and Picks
This game presents a classic clash of styles: USC’s high-octane offense against Notre Dame’s suffocating defense. While Notre Dame is the favorite, the 9.5-point spread on bet105 seems a bit wide given USC’s ability to score quickly. The Trojans have the offensive firepower to keep this game close, and a backdoor cover is a real possibility.
The Pick: USC +9.5 (-117 at bet105)
The total for this game is set at 61.5 on bet105. While both offenses are capable, the pace of play for both teams is on the slower side. Combined with Notre Dame’s elite defense and USC’s injuries at running back, the under is the more appealing play.
The Pick: Under 61.5 (-113 at bet105)
Bet105 Odds Breakdown
Bet105 offers a comprehensive menu of betting options for the USC vs. Notre Dame game. Here’s a look at some of the key odds:
Bet Type | Bet | Odds |
---|---|---|
Moneyline | USC | +254 |
Notre Dame | -324 | |
Spread | USC +9.5 | -117 |
Notre Dame -9.5 | +100 | |
Total | Over 61.5 | -105 |
Under 61.5 | -113 |
In addition to these main lines, bet105 also offers a variety of alternate spreads and totals, as well as first-half and player props. This allows you to tailor your bets to your specific predictions and risk tolerance.
Conclusion
The USC vs. Notre Dame rivalry game is a highlight of the Week 8 college football schedule. With two top-25 teams battling it out, it’s sure to be an exciting contest. For bettors, this game offers numerous opportunities, and bet105 is the place to get in on the action. Whether you’re backing the high-flying Trojans to cover the spread or banking on Notre Dame’s defense to control the game, bet105 has you covered. Bet responsibly and enjoy the game!
Other notable games for Week 8
• Louisville vs. Miami – Friday, Oct.17, 2025 at 7pm EST
• Georgia Tech vs. Duke – Saturday Oct.18 2025 at 12:00pm EST
• Georgia vs. Ole Miss – Saturday Oct.18 2025 at 3:30pm EST
• Tennessee vs. Alabama – Saturday Oct.18 2025 at 7:30pm EST
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