Virginia vs. Wake Forest Picks, Odds, and Predictions for College Football Week 11

As Week 11 of the college football season unfolds, a pivotal ACC matchup is set to take place in Charlottesville, where the Virginia Cavaliers will host the Wake Forest Demon Deacons. This game carries significant weight, especially for Virginia, as they continue their push for a spot in the ACC championship game. For bettors seeking an edge, this contest presents a fascinating mix of momentum, historical trends, and expert analysis. This article breaks down the matchup, offering predictions and a detailed look at the latest odds from bet105.

Matchup Preview: Cavaliers Eyeing ACC Glory

The Virginia Cavaliers are in the midst of an impressive season, boasting an 8-1 record and a strong 5-1 standing within the ACC. Their performance has put them in a prime position to contend for the conference title, making every remaining game a must-win. A key to their success has been their disciplined play at home, where they hold a +5 turnover margin. Their latest victory, a 31-21 win over California, was sealed by a game-ending pick-six, highlighting their ability to make decisive plays under pressure.

On the other side, the Wake Forest Demon Deacons have had a more turbulent season. Their potential was on full display two weeks ago when they secured a significant upset victory over SMU. However, they are coming off a tough 42-7 loss to Florida State. This inconsistency makes them a wildcard, capable of challenging a top team but also susceptible to a lopsided defeat. An interesting historical note for this matchup is that the Cavaliers have not managed to defeat the Demon Deacons at Scott Stadium since 2007, a trend they are heavily favored to break this Saturday.

Expert Analysis and Predictions

Across the sports analytics landscape, the consensus leans heavily in Virginia’s favor. Multiple prediction models and expert analyses point to a comfortable win for the Cavaliers. For instance, ESPN’s Football Power Index gives Virginia a commanding 78.5% chance of winning the game outright. Other outlets like Sports Betting Dime and Sporting News project a final score margin of about a touchdown or more in favor of Virginia, with score predictions around 28-21 and 28-18, respectively.

The prevailing analysis suggests that Virginia’s consistent performance, coupled with their strong turnover differential at home, will be too much for the Demon Deacons to handle. While Wake Forest has shown flashes of brilliance, their recent performance against a formidable Florida State team raises concerns about their ability to compete with a well-rounded team like Virginia.

Virginia vs. Wake Forest Odds and Betting Pick

For those looking to place a wager, bet105 provides a comprehensive set of odds for this ACC clash. Here is a breakdown of the main betting lines:

Prediction: Virginia is the clear favorite, and for good reason. Their consistent play and motivation to secure a spot in the ACC championship game make them a strong bet. While the 6.5-point spread is significant, Virginia has a 3-2 record against the spread when favored by 6.5 points or more this season. Given Wake Forest’s recent struggles against top-tier competition, the Cavaliers are well-positioned to not only win but also cover the spread.

The point total is set at 48.5. While four of Virginia’s nine games have gone over the total this season, their defense has been a reliable unit, especially at home. Considering Wake Forest’s offensive struggles in their last outing, the Under 48.5 at -113 odds presents solid value.

Final Pick: Virginia -6.5

Read our predictions for other notable games in Week 11 of NCAA Football;

Northwestern vs. USC – Friday, November 7, 2025 at 7:00pm ET
SMU vs. Boston College – Saturday, November 8, 2025 at 12:00pm ET
Oregon vs. Iowa – Saturday, November 8, 2025 at 3:30pm ET
Missouri vs. Texas A&M – Saturday, November 8, 2025 at 3:30pm ET
Florida State vs. Clemson – Saturday, November 8, 2025 at 7:00pm ET
Louisville vs. California – Saturday, November 8, 2025 at 7:00pm ET
LSU vs. Alabama – Saturday, November 8, 2025 at 7:30pm ET